#Mixed amphetamine salts trial

#Mixed amphetamine salts trial

We therefore conducted a randomized, placebo-controlled trial to determine the efficacy of extended-release mixed amphetamine salts in adults with ADHD and CUD. 17, 18 The abuse potential of a stimulant medication is of concern when considering treatment for cocaine dependence, but long-acting formulations with slow absorption and elimination mitigate this concern. 15, 16 Amphetamines have shown promise in preliminary trials for treatment of cocaine dependence without co-occurring disorders. It has been clinically observed that heavy cocaine users might require higher doses of stimulants to achieve a therapeutic effect.

13, 14 However, previous studies on stimulant treatment for combined ADHD and CUD have been inconclusive. Stimulant medications are effective for treatment of adult ADHD. 11, 12 While there are several agents for treatment of ADHD, there are no US Food and Drug Administration-approved medications for treatment of cocaine dependence. 8– 10 The combination of ADHD and CUD is associated with poor outcome.

3– 5 It is observed in 2.5% to 4.0% of the general adult population 6, 7 and 10% to 24% of those seeking treatment for substance use disorders. Attention-deficit/hyperactivity disorder (ADHD) often goes unrecognized and untreated 1 and is associated with increased risk for cocaine use disorder (CUD) 2 and other substance use disorders.